Electrochemical and spectroscopic investigations of isoniazide and its analogs with ds.DNA at physiological pH: Evaluation of biological activities

► Hydrazide INH and its analog PCH and 2,4-DHBAH interact with DNA via intercalation. ► All compounds showed good DNA binding as investigated by UV and voltammetric studies. ► Binding constant results from both techniques were in good agreement and showed stronger binding. ► Kb and n values of 2,4-DHBAH revealed its relatively stronger binding at stomach pH. ► All compounds have anti-oxidant potential; 2,4-DHBAH showed anti-bacterial activity.