Isoxazoles incorporated N-substituted decahydroquinolines: A precursor to the next generation antimicrobial drug

We report here a simple entry into N-substituted decahydroisoxazoloquinoline system with substituents at position 3 and 4 from the readily available substrates for the first time. The synthesized isoxazoloquinolines were evaluated against six bacterial and four fungal strains. The results suggest that the decahydroisoxazolo[4,3-c]quinoline scaffold has the potential to be developed into therapeutically useful antimicrobial agents.

We report here a simple entry into N-substituted decahydroisoxazoloquinoline system containing a substituent at position 3, 4 and 5 using the readily available substrates and they were evaluated for antimicrobial activities against six bacterial and four fungal strains. Compounds 3b, 3c, 3e (100 μg/mL) exhibits excellent antifungal activity compared with the standard ketoconazole.Figure optionsDownload as PowerPoint slideHighlights
► A series of isoxazoline incorporated trans-1,2-decahydroquinoline derivatives are synthesized.
► The synthesized compounds are screened for antibacterial and antifungal activities.
► All the compounds showed moderate to good inhibitory activities against all bacterial strains.
► Some compounds exhibited very high antifungal activity compared with that of standard.
► The results emphasized that the hybrid resulting from the incorporation enhances antimicrobial activities.