Synthesis and antibacterial activity of naphthyridone derivatives containing mono/difluoro-methyloxime pyrrolidine scaffolds

► The target compounds have considerable in vitro antibacterial activity. ► In vivo efficacy of 13a1, b1 is better than gemifloxacin against P. aeruginosa and MRSE. ► In vivo efficacy of 13b1 is better than gemifloxacin and ciprofloxacin against MRSA.