کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396699 | 1501197 | 2009 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-α production
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-α production. These derivatives enhance TNF-α production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-α production induced with okadaic acid (OA) in the same cell line. The diphenylmaleimide derivative 2f, was found to be the most active product, producing a strong modulation of the cytokine level.
A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-α production. 2f, was found to be the most active product.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 9, September 2009, Pages 3533–3542
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 9, September 2009, Pages 3533–3542
نویسندگان
Miguel Fernández Braña, Nuria Acero, Loreto Añorbe, Dolores Muñoz Mingarro, Francisco Llinares, Gema Domínguez,