کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397620 | 1501180 | 2011 | 12 صفحه PDF | دانلود رایگان |
1-Hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (3) was subjected to react with bifunctional compounds namely: acetylacetone, ethyl cyanoacetate, ethyl benzoylactate, diethylmalonate and ethyl acetoacetate to produce pyrazololthienotetrahydroisoquinoline derivatives 6–11. Also, heating of compound (3) with formic acid afforded triazolothienotetrahydroisoquinoline compound 5 which reacted with α-halogenated compounds to afford compounds 13a–e. Compound 13c when heated with triethylorthoformate afforded triazolo derivative 14. Also, compound 6 was used for synthesizing compounds 18–20. Representative compounds of the synthesized triazolo and pyrazolothienotetrahydroisoquinoline products were tested and evaluated as antimicrobial agents.
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► The aim of this work in this research is to synthesize new heterocyclic compounds.
► The new heterocyclic compounds contain thienotetrahydroisquinoline moiety namely: triazole, pyrazole and pyrimidine.
► Some of these compounds proved that they have antibacterial and antifungal activities.
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 2, February 2011, Pages 567–578