کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1397626 | 1501180 | 2011 | 5 صفحه PDF | دانلود رایگان |
A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substitued-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation. The products are obtained in moderate to good yields and are in a state of high purity. Moreover, title compounds have been screened for antifungal activity.
A simple, efficient and environment-friendly procedure is developed for the synthesis of antifungal active 1-substitued-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide as an energy transfer medium, basic alumina as solid support and p-TsOH as catalyst under microwave irradiation.Figure optionsDownload as PowerPoint slideResearch highlights
► I try to synthesize a new class of compounds which exhibit antifungal activity.
► These compounds are synthesized using non-conventional method of reaction activation.
► This one-pot synthesis involves the use of basic alumina as solid support and DMF as an energy transfer medium.
► This reaction is catalyzed by p-TsOH.
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 2, February 2011, Pages 631–635