کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397941 | 1501201 | 2017 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis, anti-tuberculosis activity and 3D-QSAR study of amino acid conjugates of 4-(adamantan-1-yl) group containing quinolines
ترجمه فارسی عنوان
سنتز، فعالیت ضدسل و مطالعه 3D-QSAR از ترکیبات اسید آمینه گروه 4- (ادمنتین-1-ایل) شامل کوینولین
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کلمات کلیدی
بیماری سل؛ کوینولین حلقه تعویض. CoMFA؛ ترکیبات اسید آمینه؛ ضد سل
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
The synthesis, antimycobacterial activity and 3D-QSAR study of two series of 4-(adamantan-1-yl) group containing quinolines conjugated to amino acids are described. The most potent analogs displayed in vitro antimycobacterial activity ranging between 1.00 and 3.125 μg/mL. To understand the relationship between structure and activity, a 3D-QSAR analysis has been carried out by Comparative Molecular Field Analysis (CoMFA). The activities of molecules in the test sets were nicely predicted by the CoMFA model generated with field alignment. The best model was obtained using atom-fit alignment. Based on the molecular fields the relationships between structure and activity were easily rationalized.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 5, May 2009, Pages 2017–2029
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 5, May 2009, Pages 2017–2029
نویسندگان
Amit Nayyar, Sanjay R. Patel, Mushtaque Shaikh, Evans Coutinho, Rahul Jain,