کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399259 | 1501156 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC50 of 7.8 μM.
Figure optionsDownload as PowerPoint slideHighlights
► New substituted 1,4-naphthoquinones were synthesized.
► The products exhibited substantial activity against T. cruzi.
► The more active compound 9 showed a IC50 of 7.8 μM against T. cruzi.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 60, February 2013, Pages 51–56
Journal: European Journal of Medicinal Chemistry - Volume 60, February 2013, Pages 51–56
نویسندگان
Adriano Olímpio da Silva, Rosangela da Silva Lopes, Ricardo Vieira de Lima, Camila Santos Suniga Tozatti, Maria Rita Marques, Sérgio de Albuquerque, Adilson Beatriz, Dênis Pires de Lima,