کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1400078 | 1501239 | 2006 | 9 صفحه PDF | دانلود رایگان |
The synthesis of a series of α-methylene-γ-butyrolactones (compounds 4a, 4b, 6–12, 16, 17) and α,β-unsaturated-δ-lactones (compounds 19−23, 25, 26) starting from 4,4-dimethyldihydrofuran-2,3-dione (1) has been described. Their chemical structures were assigned by spectroscopic evidence. These new compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with their IC50 values ranging from 0.88 to > 20.00 μM.
The synthesis of a series of α-methylene-γ-butyrolactones and α, β-unsaturated-δ-lactones has been described. Their chemical structures were assigned by spectroscopic evidence. The compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with IC50 values ranging from 0.88 to > 20.00 μM.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 2, February 2006, Pages 192–200