کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
14186 1186 2016 10 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Prevascularization in tissue engineering: Current concepts and future directions
ترجمه فارسی عنوان
قبل از واسکولاریزاسیون قرنیه در مهندسی بافت: مفاهیم رایج و جهت گیری های آینده
کلمات کلیدی
مهندسی بافت؛ آنژیوژنز؛ واسکولاریزاسیون قرنیه؛ سلول های اندوتلیال؛ سلول های بنیادی؛ قطعات عروق؛ داربست؛ حلقه شریانی؛ میکروسیالی
Tissue engineering; Angiogenesis; Vascularization; Endothelial cells; Stem cells; Microvascular fragments; Scaffold; Arteriovenous loop; Microfluidic
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

The survival of engineered tissue constructs during the initial phase after their implantation depends on the rapid development of an adequate vascularization. This, in turn, is a major prerequisite for the constructs' long-term function. ‘Prevascularization’ has emerged as a promising concept in tissue engineering, aiming at the generation of a preformed microvasculature in tissue constructs prior to their implantation. This should shorten the time period during which the constructs are avascular and suffer hypoxic conditions. Herein, we provide an overview of current strategies for the generation of preformed microvascular networks within tissue constructs. In vitro approaches use cell seeding, spheroid formation or cell sheet technologies. In situ approaches use the body as a natural bioreactor to induce vascularization by angiogenic ingrowth or flap and arteriovenous (AV)-loop techniques. In future, these strategies may be supplemented by the transplantation of adipose tissue-derived microvascular fragments or the in vitro generation of highly organized microvascular networks by means of sophisticated microscale technologies and microfluidic systems. The further advancement of these prevascularization concepts and their adaptation to individual therapeutic interventions will markedly contribute to a broad implementation of tissue engineering applications into clinical practice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biotechnology Advances - Volume 34, Issue 2, March–April 2016, Pages 112–121
نویسندگان
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