A zeolite modified carbon paste electrode as useful sensor for voltammetric determination of acetaminophen

• Modified carbon paste electrode with Co(II)-zeolite A improved the voltammetric current in determination of acetaminophen.
• Modified electrode is applicable for acetaminophen in real samples.
• The proposed method has good reproducibility and repeatability.

The voltammetric behavior of a carbon paste electrode modified with Co(II)-exchanged zeolite A (Co(II)-A/ZMCPE) for determination of acetaminophen was studied. The proposed electrode showed a diffusion controlled reaction with the electron transfer rate constant (Ks) of 0.44 s− 1 and charge transfer coefficient of 0.73 in the absence of acetaminophen. A linear voltammetric response was obtained in the range of 0.1 to 190 μmol L− 1 of acetaminophen [r2 = 0.9979, r = 0.9989 (n = 10)] with a detection limit of 0.04 μmol L− 1. The method was successfully applied to the analysis of acetaminophen in some drugs.