کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1428423 | 1509173 | 2015 | 6 صفحه PDF | دانلود رایگان |
کلیدواژگان
1. مقدمه
2. ریخته گری حلال/ آب شویی ذره ای
3. جداسازی فازی ناشی از حرارت (TIPS)
4. قالب ریزی مذاب
5. اسفنج گازی
6. خشک کردن انجمادی امولسیون
7. نتایج
• Current state of art in the area of tissue engineering porous scaffolds fabrication is outlined.
• Various possibilities to control the pore size and shape, interconnectivity and total porosity are described.
• Specific importance is placed on different polyurethane systems used in scaffold fabrication.
The aim of tissue engineering is the fabrication of three-dimensional scaffolds that can be used for the reconstruction and regeneration of damaged or deformed tissues and organs. A wide variety of techniques have been developed to create either fibrous or porous scaffolds from polymers, metals, composite materials and ceramics. However, the most promising materials are biodegradable polymers due to their comprehensive mechanical properties, ability to control the rate of degradation and similarities to natural tissue structures. Polyurethanes (PUs) are attractive candidates for scaffold fabrication, since they are biocompatible, and have excellent mechanical properties and mechanical flexibility. PU can be applied to various methods of porous scaffold fabrication, among which are solvent casting/particulate leaching, thermally induced phase separation, gas foaming, emulsion freeze-drying and melt moulding. Scaffold properties obtained by these techniques, including pore size, interconnectivity and total porosity, all depend on the thermal processing parameters, and the porogen agent and solvents used. In this review, various polyurethane systems for scaffolds are discussed, as well as methods of fabrication, including the latest developments, and their advantages and disadvantages.
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Journal: Materials Science and Engineering: C - Volume 48, 1 March 2015, Pages 586–591