The effect of temperature on mass transfer and thermodynamic parameters in the removal of amoxicillin via hollow fiber supported liquid membrane

• The effect of temperature on the separation of amoxicillin via HFSLM was studied.
• The highest percentage of extraction of amoxicillin was 89.65% at 318.15 K.
• The activation energy (Ea) of amoxicillin extraction was found to be 44.28 kJ/mol.
• Amoxicillin extraction was endothermic (-ΔHex0) while (+ΔSex0) and (-ΔGex0) were forward reaction.
• km < kf, implying that mass transfer in membrane phase was rate controlling step.

The influence of temperature on the separation of amoxicillin via HFSLM containing the carrier Aliquat 336 was systematically investigated. Mass-transfer parameters including distribution ratio and flux as well as thermodynamic properties namely ΔH and ΔG were also determined at different temperatures ranging from 278.15 K to 318.15 K. The positive value of the enthalpy change (24.5778 kJ/mol) indicated that the extraction process is endothermic reaction. Further, the positive value of the entropy change (112.0145 J/mol K) and the negative value of the Gibbs free-energy indicated that the extraction process is forward reaction. It was found that by increasing the temperature of the system from 278.15 to 318.15 K, extraction of amoxicillin increased from 81.81% to 89.65% and the stripping of amoxicillin increased from 76.63% to 84.70% respectively. Activation energy (Ea) of amoxicillin extraction was found to be 44.28 kJ/mol. This implied that the chemical reaction was the mass transfer controlling step. The mass transfer coefficients in the membrane phase were found to be less than the mass transfer coefficients in the feed phase within the range of temperatures i.e. 278.15–318.15 K. This implied that the mass transfer process in the membrane phase was the rate controlling step.

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