Synthesis of mesoporous carbon spheres and release of albendazole

• MCS with no cytotoxicity and good biocompatibility was synthesized.
• The release rates of ABZ from MCS were significantly improved.
• The corresponding release parameters were firstly calculated by Weibull function.

A facile stirring method was developed to synthesize mesoporous carbon spheres (MCS), which were then loaded with the poorly water-soluble drug, albendazole (ABZ), to enhance its solubility and dissolution kinetics. The effects of the mass ratio of glucose/silica on the physicochemical properties of the resulting MCS were investigated. MCS exhibits no cytotoxicity and good biocompatibility. ABZ was effectively loaded into the mesopores in an amorphous state, and marked improvements in its dissolution kinetics were observed after loading. Drug release behaviors were well simulated by the Weibull function.

Figure as shown was the formation scheme of mesoporous carbon spheres (MCS) by the stirring method, in which the structure parameters and morphology of MCS could be adjusted and changed by simply varying the mass ratio of glucose. Increases in the ratio of glucose significantly strengthened the framework of the MCS and prevented mesopore shrinkage. ABZ was then effectively loaded into the mesopores and marked improvements in its dissolution kinetics were observed after loading because of the amorphous state, high solubility, and dispersibility of the drug after loading into the pore channels of the MCS.Figure optionsDownload as PowerPoint slide