A biofunctional-modified silk fibroin scaffold with mimic reconstructed extracellular matrix of decellularized pulp/collagen/fibronectin for bone tissue engineering in alveolar bone resorption

• The decellularized pulp/collagen/fibronectin organized as fibril network.
• The modified silk scaffold had effective biofunctionalities.
• The modified silk scaffold promised for bone alveolar resorption.

A modified silk fibroin scaffold with mimic reconstructed extracellular matrix of decellularized pulp/collagen/fibronectin was proposed for bone tissue engineering in alveolar bone resorption. Silk fibroin scaffolds were fabricated by freeze-drying before modification by coating in a decellularized pulp/collagen/fibronectin solution. The extracellular matrix reconstruction of the decellularized pulp/collagen/fibronectin and the morphology and biofunctionalities of the modified scaffolds were evaluated. The results showed that decellularized pulp/collagen/fibronectin organized into a dense dendrite structure and adhered in the scaffold in a fibrillar network. The modified scaffold showed predominant biofunctionalities and promise for bone tissue engineering in alveolar bone resorption.

Figure optionsDownload as PowerPoint slide