کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1642173 | 1517222 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Biodegradable shape-memory poly(ε-caprolactone)/polyhedral oligomeric silsequioxane nanocomposites: sustained drug release and hydrolytic degradation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Biodegradable shape-memory poly(ε-caprolactone) (PCL)/trisilanolphenyl polyhedral oligomeric silsequioxane (TspPOSS) nanocomposite films loaded with drug (theophylline) were prepared by a solution blending followed by solvent casting method. PCL/TspPOSS nanocomposite (90 wt/10 wt) loaded with 10 wt% drug exhibited fairly good thermally-triggered shape memory behavior with a shape fixity ratio of 81% and shape recovery ratio of 85%. In vitro drug release studies in the phosphate buffer solution (PBS; pH=7.4) revealed that the TspPOSS nanocrystals caused sustained release of the drug for the nanocomposites. It was also shown that TspPOSS enhanced the hydrolytic degradation rate of the PCL matrix.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Letters - Volume 166, 1 March 2016, Pages 125-128
Journal: Materials Letters - Volume 166, 1 March 2016, Pages 125-128
نویسندگان
Muhammad Kashif, Bo-mi Yun, Kang-Suk Lee, Young-Wook Chang,