Preparation of purpurin-18 loaded magnetic nanocarriers in cottonseed oil for photodynamic therapy

Purpurin-18 loaded magnetic silica nanocarriers for photodynamic therapy (PDT) were prepared in cottonseed oil by W/O micro-emulsion method. The size of the nanocarriers was ranged from 20 to 30 nm obtained from transmission electron micrograph observation. The photodynamic drug purpurin-18 was successfully enwrapped in the nanocarriers characterized by ultraviolet–visible absorption and Fourier transform infrared spectroscopy spectra. The generation of singlet oxygen (1O2) was followed by N,N-dimethyl-4-nitrosoaniline (RNO) bleaching assay. The loss of RNO absorbance at 440 nm versus irradiation time displayed that purpurin-18 could play a role in normal.