Distortion correction of EPI data using multimodal nonrigid registration with an anisotropic regularization

The new registration method was evaluated with one monomodal phantom data set and two multimodal human brain data sets (BrainSuite trainings data, SPM Subject data). By comparing with recent and efficient techniques of the state of the art, in the monomodal case, the new approach achieves results comparable to the sum of squared differences as data term. In the multimodal cases, our new registration strategy improves the mean of the SCD from 0.96 ± 0.11 to 0.60 ± 0.13 in case of the SPM Subject data and from 0.92 ± 0.07 to 0.78 ± 0.11 in case of the BrainSuite trainings data.