کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1855603 1529400 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel dynamic field-matching technique for treatment of patients with para-aortic node-positive cervical cancer: Clinical experience
ترجمه فارسی عنوان
روش تطبیق درست جدید پویا برای درمان بیماران مبتلا به سرطان دهانه رحم گره مثبت شبه آئورت: تجربه بالینی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک هسته ای و انرژی بالا
چکیده انگلیسی

AimTo report outcomes for patients with para-aortic lymph node positive cervical cancer treated with a dynamic field-matching technique.BackgroundPET staging of cervical cancer has increased identification of patients with para-aortic lymph node metastasis. IMRT enables dose escalation in this area, but matching IMRT fields with traditional whole pelvis fields presents a challenge.Materials and methodsFrom 2003 to 2012, 20 patients with cervical cancer and para-aortic lymph node metastasis were treated utilizing the dynamic field-matching technique. As opposed to single-isocenter half-beam junction techniques, this technique employs wedge-shaped dose junctions for the abutment of fields. We reviewed the records of all patients who completed treatment with the technique and abstracted treatment, toxicity, and disease-related outcome data for analysis.ResultsMedian prescribed dose to the whole pelvis field was 45 Gy and para-aortic IMRT field 50.4 Gy. All but 3 patients underwent HDR (13 pts) or LDR (4 pts) brachytherapy. All patients developed lower GI toxicity; 10 grade 1, 9 grade 2, and 1 grade 4 (enterovaginal fistula). Median DFS was 12.4 months with 1 and 2-year DFS 60.0% and 38.1%. One-year OS was 83.7% and 2-year OS, 64.4%. A total of 10 patients developed recurrence; none occurred at the matched junction.ConclusionsThe dynamic field-matching technique provides a means for joining conventional whole pelvis fields and para-aortic IMRT fields that substantially reduces dose deviations at the junction due to field mismatch. Treatment with the dynamic matching technique is simple, effective, and tolerated with no apparent increase in toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reports of Practical Oncology & Radiotherapy - Volume 21, Issue 1, January–February 2016, Pages 37–41
نویسندگان
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