کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1860500 | 1037436 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proton transfer studies in CGC+ assembly
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
فیزیک و نجوم (عمومی)
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چکیده انگلیسی
We have designed and analyzed a molecular model of a generic triple helix DNA base structure - the cytosine-guanine-cytosine (CGC+) assembly. The complex has been investigated for the ability of a concerted proton transfer from cytosine to guanine. Ab initio calculations have been preformed using Unrestricted Hartree-Fock (UHF) method with 6-31Gâ+ basis set. In order to determine possible reaction paths, the potential map has been constructed pointing the most stable configuration for the process to occur. Based on this observation, we have estimated a transmission coefficient for the transfer and found no support for a concerted motion. The effect of fluctuations of the barrier height on the kinetics is also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physics Letters A - Volume 374, Issue 1, 14 December 2009, Pages 50-54
Journal: Physics Letters A - Volume 374, Issue 1, 14 December 2009, Pages 50-54
نویسندگان
MichaŠŻabicki, Ewa Gudowska-Nowak, Sighart F. Fischer,