Stochastic fluctuation induced the competition between extinction and recurrence in a model of tumor growth

We investigate the phenomenon that stochastic fluctuation induced the competition between tumor extinction and recurrence in the model of tumor growth derived from the catalytic Michaelis–Menten reaction. We analyze the probability transitions between the extinction state and the state of the stable tumor by the Mean First Extinction Time (MFET) and Mean First Return Time (MFRT). It is found that the positional fluctuations hinder the transition, but the environmental fluctuations, to a certain level, facilitate the tumor extinction. The observed behavior could be used as prior information for the treatment of cancer.

► Stochastic fluctuation induced the competition between extinction and recurrence.
► The probability transitions are investigated.
► The positional fluctuations hinder the transition.
► The environmental fluctuations, to a certain level, facilitate the tumor extinction.
► The observed behavior can be used as prior information for the treatment of cancer.