کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879370 | 1042563 | 2010 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Full automation of 68Ga labelling of DOTA-peptides including cation exchange prepurification
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
Here we describe a fully automated approach for the synthesis of 68Ga-labelled DOTA-peptides based on pre-concentration and purification of the generator eluate by using a cation exchange-cartridge and its comparison with fully automated direct labelling applying fractionated elution. Pre-concentration of the eluate on a cation exchange cartridge both using a resin-based and a disposable cation-exchange cartridge efficiently removed 68Ge as well as major metal contaminations with Fe and Zn. This resulted in a high labelling efficiency of DOTA-peptides at high specific activity (SA) with short synthesis times.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 68, Issue 2, February 2010, Pages 297–302
Journal: Applied Radiation and Isotopes - Volume 68, Issue 2, February 2010, Pages 297–302
نویسندگان
M. Ocak, M. Antretter, R. Knopp, F. Kunkel, M. Petrik, N. Bergisadi, C. Decristoforo,