کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1879375 | 1042563 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
N-[11C]-methyl-hydroxyfasudil was synthesized as a new potential radiotracer for rho-kinases (ROCKs) via a two-step one-pot radiosynthesis. The first step was the methylation of the precursor N-Boc-hydroxyfasudil-sodium salt/benzo-15-crown-5 complex with [11C]methyl iodide. The second step involved deprotection of the tert-butoxycarbonyl protecting group. The radiochemical and chemical purities of N-[11C]-methyl-hydroxyfasudil were >95% and specific radioactivity was 1565–2565 mCi/μmol at the end of the synthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 68, Issue 2, February 2010, Pages 325–328
Journal: Applied Radiation and Isotopes - Volume 68, Issue 2, February 2010, Pages 325–328
نویسندگان
Ana C. Valdivia, Samantha Mason, Jeffrey Collins, Kenneth R. Buckley, Paul Coletta, Rob S. Beanlands, Jean N. DaSilva,