کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928503 1050363 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Cj0588 protein is a Campylobacter jejuni RNA methyltransferase
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
The Cj0588 protein is a Campylobacter jejuni RNA methyltransferase
چکیده انگلیسی


• Methylation of 50S.
• Enzymatic properties.
• Ribosome profile.
• Motility.
• MIC of capreomycin.

TlyA proteins belong to 2′-O-methyltransferases. Methylation is a common posttranscriptional RNA modification. The Campylobacter jejuni Cj0588 protein belongs to the TlyAI protein family and is a rRNA methyltransferase. Methylation of ribosomal RNA catalyzed by Cj0588 appears to have an impact on the biology of the cell. Presence of the cj0588 gene in bacteria appears to be important for ribosome stability and virulence properties. Absence of the Cj0588 protein causes accumulation of the 50S ribosomal subunits, reduction in the amount of functional 70S ribosomes and confers increase resistance to capreomycin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 448, Issue 3, 6 June 2014, Pages 298–302
نویسندگان
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