کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1930380 | 1050507 | 2011 | 4 صفحه PDF | دانلود رایگان |
ABCA1 is a key element of cellular cholesterol homeostasis. ApoE K/O mice fed with high-fat diet were infused with anti-ABCA1 antibody or control IgM. Infusion of anti-ABCA1 antibody led to 72% increase in the area of atherosclerotic plaque in aorta. After 16 weeks on high-fat diet plasma level of high density lipoprotein cholesterol (HDL-C) was reduced in control group, but was unchanged in mice infused with anti-ABCA1 antibody. Total plasma cholesterol level was elevated while the capacity of plasma to support cholesterol efflux ex vivo was reduced after 16 weeks on high-fat diet; the effects were similar in the two groups. We conclude that functional blocking of ABCA1-dependent cholesterol efflux stimulates development of atherosclerosis in apoE K/O mice independently from HDL-C levels.
► Global functional knockdown of ABCA1 increases atherosclerosis.
► ABCA1 knockdown prevents reduction of plasma HDL cholesterol.
► The capacity of plasma to support cholesterol efflux is not affected by the ABCA1 knockdown.
Journal: Biochemical and Biophysical Research Communications - Volume 412, Issue 3, 2 September 2011, Pages 446–449