کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1936492 | 1050692 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Roles of neuropeptides in O,O,S-trimethylphosphorothioate (OOS-TMP)-induced anorexia in mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
O,O,S-Trimethylphosphorothioate (OOS-TMP), an impurity present in various organophosphorus insecticides, has previously been shown to induce hypophagia. The major goal of this study was to investigate its mechanism of action. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injection transiently induced hypophagia at a dose of 5 mg/kg within 6 h, without causing lung injury. Hypophagia was accompanied by up-regulation of corticotropin releasing factor (CRF) (2.92 ± 0.45 vs. 1.7 ± 0.5, at 2 h after i.c.v., 3.40 ± 1.38 vs. 1.76 ± 0.41 at 6 h after i.p., P < 0.05) in the hypothalamus. After i.c.v. injection, hypophagia recovered by 6 h after dosing. At doses higher than 5 mg/kg, i.c.v. injection induced continuous hypophagia from 20 min to 72 h after dosing, accompanied by hypothermia and lung injury. OOS-TMP was considered to induce hypophagia through enhancing expression of CRF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 362, Issue 1, 12 October 2007, Pages 177-182
Journal: Biochemical and Biophysical Research Communications - Volume 362, Issue 1, 12 October 2007, Pages 177-182
نویسندگان
Linfang Huang, Megumi Toyoshima, Akihiro Asakawa, Kayoko Inoue, Kouji Harada, Tomomi Kinoshita, Akio Koizumi,