کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1949001 1537698 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stearoyl-CoA desaturase-1 and adaptive stress signaling
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Stearoyl-CoA desaturase-1 and adaptive stress signaling
چکیده انگلیسی


• SCD-1 is a controversial drug target for metabolic diseases, skin disorders and cancer.
• The two faces of SCD-1 depend on stress-inductive, stress-preventive and survival signaling.
• Mechanisms and lipid factors mediating the pleiotropic bioactivities of SCD-1 are emerging.

Stearoyl-CoA desaturase (SCD), the central enzyme in the biosynthesis of monounsaturated fatty acids, introduces a cis-Δ9 double bond into saturated fatty acids. SCD-1 has been proposed as promising target for the treatment of cancer, skin disorders and metabolic diseases, and strong efforts have been made during the last decade to develop clinical drug candidates. While the regulation and biological implications of SCD-1 have been extensively reviewed, the molecular mechanisms through which SCD-1 mediates cellular responses remained a mystery. An important aspect seems to be that SCD-1 induces adaptive stress signaling that maintains cellular persistence and fosters survival and cellular functionality under distinct pathological conditions. Here, we will first provide an overview about the function, regulation, structure and mechanism of SCD-1 and then focus on mitogenic and stress-related signal transduction pathways orchestrated by SCD-1. Moreover, we will discuss molecular mechanisms and potential lipid factors that link SCD-1 activity with initial signal transduction.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1861, Issue 11, November 2016, Pages 1719–1726
نویسندگان
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