Electrospray mass spectrometric characterization of hemoglobin Q (Hb Q-India) and a double mutant hemoglobin S/D in clinical samples

The site of mutation in hemoglobin Q-India is identified as α64D → H which differs from mutations α74D → H in Hb Q-Thailand and α75D → H in Hb Q-Iran. Mass spectrometric analysis of hemoglobins from a patient and her parents suggests inheritance of mutant β globin genes from both parents.