Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: Insights into the antagonism of the hypolipidemic agent Z-guggulsterone
Keywords: HDX; hydrogen/deuterium exchange; LC-ESI-MS; liquid chromatography electrospray ionization mass spectrometry; FXR-LBD; farnesoid X receptor ligand binding domain; LBC; ligand binding cavity; CDCA; chenodeoxycholic acid; GG; Z-guggulsterone; 6ECDCA; 6-et