کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1978379 | 1061540 | 2008 | 6 صفحه PDF | دانلود رایگان |
The Metal-responsive Transcription Factor (MTF-1) serves as an essential regulator of Zn2+ homeostasis via the activation of metallothionein gene expression. Only a single mtf-1 gene has been identified in any organism investigated previously. We report here the first evidence of the existence of two genes encoding MTF-1 proteins (mtf-1.1 and mtf-1.2). The expression patterns were followed in the liver, kidney, muscle, brain and heart by means of Northern hybridization and reverse transcription coupled polymerase chain reactions (RT-PCR). mtf-1.1 mRNA was detected in all tissues examined, with the highest level in the brain, and the lowest in the kidney and the liver. mtf-1.2 expression was detected exclusively in the brain. Cold shock and Cd2+ exposure influence the gene expression at the transcriptional level, in a stress-specific manner.
Journal: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology - Volume 148, Issue 3, September 2008, Pages 238–243