کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1991554 | 1541011 | 2014 | 5 صفحه PDF | دانلود رایگان |
Pregnancy involves diverse changes in brain function that implicate a re-organization in neuronal cytoskeleton. In this physiological state, the brain is in contact with several hormones that it has never been exposed, as well as with very high levels of hormones that the brain has been in touch throughout life. Among the latter hormones are progesterone and estradiol which regulate several brain functions, including learning, memory, neuroprotection, and the display of sexual and maternal behavior. These functions involve changes in the structure and organization of neurons and glial cells that require the participation of cytoskeletal proteins whose expression and activity is regulated by estradiol and progesterone. We have found that the expression pattern of Microtubule Associated Protein 2, Tau, and Glial Fibrillary Acidic Protein changes in a tissue-specific manner in the brain of the rat throughout gestation and the start of lactation, suggesting that these proteins participate in the plastic changes observed in the brain during pregnancy.This article is part of a Special Issue entitled ‘Pregnancy and Steroids’.
► Expression of cytoskeletal proteins changes in the rat brain during pregnancy.
► Sex steroids regulate the expression of cytoskeletal proteins in the brain.
► MAP2, Tau, and GFAP expression changes in a tissue-specific manner in the pregnant rat brain.
Journal: The Journal of Steroid Biochemistry and Molecular Biology - Volume 139, January 2014, Pages 154–158