Solubility of fluvoxamine maleate in supercritical carbon dioxide

• Static method coupled with gravimetric method is used to measure solubility of fluvoxamine maleate.
• Solubility of cetirizine was in the range of 1.23 × 10−5 to 4.45 × 10−4 based on the mole fraction.
• Four different semi-empirical correlation and PR EoS are used to model the measured solubility data.
• Among the different used models, Chrastil model leads to the lowest AARD% of 10.3%.

During the past decades, processing and engineering the drug particle using new proposed methods have gained an increasing attention. Among the different methods, using supercritical fluids technology is one of the most desired one. In this way, measuring and knowing the solubility of pharmaceuticals in supercritical fluids are one of the most critical parameters must be systematically categorized as a function of pressures and temperatures. Regarding this fact, solubility of fluvoxamine maleate in supercritical carbon dioxide in wide ranges of temperature (308–338 K) and pressure (200–400 bar) was measured using a static method coupled with gravimetric method which is in the range of 1.23 × 10−5 to 4.45 × 10−4 based on the mole fraction. Finally, the solubility data are modeled using four different semi-empirical density-based correlations namely Mendez Santiago-Teja (MST), Bartle et al., Chrastil and Kumar and Johnston (KJ) models. The obtained results reveal that amongst the utilized correlations, Chrastil model leads to the most accurate results compared with the other examined correlations with average absolute relative deviation percent (AARD%) of 10.8%. Besides, the solubility data are modeled using Peng–Robinson equation of state which no satisfactory results are obtained since the AARD% for all of the examined isotherms are in the range of 58.01–67.04%.

Schematic diagram of the used apparatus.Figure optionsDownload as PowerPoint slide