کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2032465 1542864 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii (Harms) J. Leonard stem barks (Caesalpiniaceae) in mice and rats
ترجمه فارسی عنوان
مطالعات مقدماتی سمیت حاد و زیرمزمن عصاره آب گیبورتیا تسمننی (Harms) J. لئونارد (Caesalpiniaceae) در موش و موش های صحرایی
کلمات کلیدی
Guibourtia tessmannii؛ ساقه ؛ عصاره گیاهی؛ داروی گیاهی؛ سمی بودن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

ObjectiveTo investigate the toxicity of aqueous extract of Guibourtia tessmannii (Harms) J. Leonard (G. tessmannii) and evaluate its safety.MethodsNMRI mice were used to determine the acute toxicity of G. tessmannii. Increasing concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 days. In order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ weights.ResultsLD50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical parameters.ConclusionsThe results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Pacific Journal of Tropical Biomedicine - Volume 6, Issue 6, June 2016, Pages 506–510
نویسندگان
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