کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2035025 1072125 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism
ترجمه فارسی عنوان
رفتارهای تحمل پذیری میکروبی تعاونی در متمایز میزبان-میکروبیوتا
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
چکیده انگلیسی

Animal defense strategies against microbes are most often thought of as a function of the immune system, the primary function of which is to sense and kill microbes through the execution of resistance mechanisms. However, this antagonistic view creates complications for our understanding of beneficial host-microbe interactions. Pathogenic microbes are described as employing a few common behaviors that promote their fitness at the expense of host health and fitness. Here, a complementary framework is proposed to suggest that, in addition to pathogens, beneficial microbes have evolved behaviors to manipulate host processes in order to promote their own fitness and do so through the promotion of host health and fitness. In this Perspective, I explore the idea that patterns or behaviors traditionally ascribed to pathogenic microbes are also employed by beneficial microbes to promote host tolerance defense strategies. Such strategies would promote host health without having a negative impact on microbial fitness and would thereby yield cooperative evolutionary dynamics that are likely required to drive mutualistic co-evolution of hosts and microbes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 165, Issue 6, 2 June 2016, Pages 1323–1331
نویسندگان
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