Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection

► Lung regeneration after H1N1 influenza infection involves p63-expressing DASCs ► Pedigrees of cloned DASCs are intrinsically committed to form alveoli in vitro ► DASCs radiate to damaged lung to form “Krt5 pods” that mature to incipient alveoli ► Expression profile of Krt5+ pods reflects dynamic intermediates in lung regeneration