کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2036157 1072247 2011 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth
چکیده انگلیسی

SummaryThroughout life, adult organs continually adapt to variable environmental factors. Adaptive mechanisms must fundamentally differ from homeostatic maintenance, but little is known about how physiological factors elicit tissue remodeling. Here, we show that specialized stem cell responses underlie the adaptive resizing of a mature organ. In the adult Drosophila midgut, intestinal stem cells interpret a nutrient cue to “break homeostasis” and drive growth when food is abundant. Activated in part by niche production of insulin, stem cells direct a growth program through two altered modes of behavior: accelerated division rates and predominance of symmetric division fates. Together, these altered modes produce a net increase in total intestinal cells, which is reversed upon withdrawal of food. Thus, tissue renewal programs are not committed to maintain cellular equilibrium; stem cells can remodel organs in response to physiological triggers.

Graphical AbstractFigure optionsDownload high-quality image (283 K)Download as PowerPoint slideHighlights
► Onset of feeding triggers a stem cell response to increase total intestinal cells
► Niche production of insulin activates stem cell divisions beyond maintenance levels
► Symmetric stem cell divisions predominate specifically during the growth response
► Intestinal growth is reversible and repeatable with dietary change

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 147, Issue 3, 28 October 2011, Pages 603–614
نویسندگان
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