کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2036353 | 1072258 | 2010 | 12 صفحه PDF | دانلود رایگان |
SummaryIn the mouse olfactory system, the anatomical locations of olfactory sensory neurons (OSNs) roughly correlate with their axonal projection sites along the dorsal-ventral (D-V) axis of the olfactory bulb (OB). Here we report that an axon guidance receptor, Neuropilin-2 (Nrp2), and its repulsive ligand, Semaphorin-3F (Sema3F), are expressed by OSNs in a complementary manner that is important for establishing olfactory map topography. Sema3F is secreted by early-arriving axons of OSNs and is deposited at the anterodorsal OB to repel Nrp2-positive axons that arrive later. Sequential arrival of OSN axons as well as the graded and complementary expression of Nrp2 and Sema3F by OSNs help to form the topographic order along the D-V axis.
Graphical AbstractFigure optionsDownload high-quality image (304 K)Download as PowerPoint slideHighlights
► Axonal extension occurs sequentially along the D-V axis during development
► Both Nrp2 and Sema3F are expressed by OSNs in a complementary manner
► Sema3F is delivered to the dorsal region of the OB by early-arriving OSN axons
► Sema3F prevents the late-arriving Nrp2+ axons from invading the dorsal OB
Journal: - Volume 141, Issue 6, 11 June 2010, Pages 1056–1067