کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2047423 | 1073975 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex](/preview/png/2047423.png)
چکیده انگلیسی
Mitochondrial ATP synthase is a motor enzyme in which a central shaft rotates in the stator casings fixed with the peripheral stator stalk. When expression of d-subunit, a stator stalk component, was knocked-down, human cells could not form ATP synthase holocomplex and instead accumulated two subcomplexes, one containing a central rotor shaft plus catalytic subunits (F1-c-ring) and the other containing stator stalk components (“b-e-g” complex). F1-c-ring was also formed when expression of mitochondrial DNA-coded a-subunit and A6L was suppressed. Thus, the central rotor shaft and the stator stalk are formed separately and they assemble later. Similar assembly strategy has been known for ATP synthase of yeast and Escherichia coli and could be common to all organisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 589, Issue 19, Part B, 14 September 2015, Pages 2707-2712
Journal: FEBS Letters - Volume 589, Issue 19, Part B, 14 September 2015, Pages 2707-2712
نویسندگان
Makoto Fujikawa, Kanako Sugawara, Tsutomu Tanabe, Masasuke Yoshida,