کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048116 | 1074063 | 2012 | 6 صفحه PDF | دانلود رایگان |
An excess of interleukin 17 (IL-17) may contribute to chronic inflammatory disorders, but mechanisms that regulate IL-17 in immune cells are unclear. Here we report that tristetraprolin (TTP) inhibits IL-17 production in human T cell lines. Overexpression of TTP decreased the expression of IL-17. Conversely, TTP inhibition by siRNA increased IL-17 production. IL-17 mRNA contains eight AREs within its 3′UTR. TTP bound directly to the IL-17 mRNA 3′UTR at a location between the fourth and seventh AREs and enhanced decay of IL-17 transcripts. These results suggest that TTP could control IL-17-mediated inflammation.
► Overexpression of TTP inhibits IL-17 production in human T cells.
► TTP binds to the ARE within the IL-17 3′UTR.
► TTP enhances the decay of IL-17 mRNA.
► TTP can be a novel target to control IL-17 production.
Journal: FEBS Letters - Volume 586, Issue 1, 2 January 2012, Pages 41–46