کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2048248 | 1074072 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mice lacking Ran binding protein 1 are viable and show male infertility
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The small GTPase Ran plays important roles in multiple aspects of cellular function. Maximal RanGAP activity is achieved with the aid of RanBP1 and/or presumably of RanBP2. Here, we show that RanBP1-knockout mice are unexpectedly viable, and exhibit male infertility due to a spermatogenesis arrest, presumably caused by down-regulation of RanBP2 during spermatogenesis. Indeed, siRNA-mediated depletion of RanBP2 caused severe cell death only in RanBP1-deficient MEFs, indicating that simultaneous depletion of RanBP1 and RanBP2 severely affects normal cell viability. Collectively, we conclude that the dramatic decrease in “RanBP” activity impairs germ cell viability and affects spermatogenesis decisively in RanBP1-knockout mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 585, Issue 5, 9 March 2011, Pages 791–796
Journal: FEBS Letters - Volume 585, Issue 5, 9 March 2011, Pages 791–796
نویسندگان
Masahiro Nagai, Tetsuji Moriyama, Rashid Mehmood, Keizo Tokuhiro, Masahito Ikawa, Masaru Okabe, Hiromitsu Tanaka, Yoshihiro Yoneda,