کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2049904 1074146 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The immunostimulatory effect of IL-1β in vivo is blocked by antisense peptides complementary to the loop sequence 163-171
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The immunostimulatory effect of IL-1β in vivo is blocked by antisense peptides complementary to the loop sequence 163-171
چکیده انگلیسی
Antisense (AS) peptides complementary to the β-bulge surface loop VQGEESNDK (Boraschi loop) of the cytokine interleukin-1β (IL-1β) have been shown to bind IL-1β at the Boraschi loop position, and to inhibit some of the IL-1β-mediated biological effects in vitro. Here we show that primary AS peptide FVITFFSLY inhibits IL-1β-mediated immunostimulation in vivo in a dose-dependent fashion, while inactive on IL-1β-induced inflammation, an effect that takes place independently of the Boraschi loop. To the best of our knowledge, this is the first time that an AS peptide has been used successfully in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 583, Issue 4, 18 February 2009, Pages 792-796
نویسندگان
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