کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2069371 | 1078381 | 2006 | 11 صفحه PDF | دانلود رایگان |
Mitochondrial Ca2+ and its relation with the contraction induced by phenylephrine was investigated. In normal Ca2+, carbonyl cyanide p-(trifluoro-methoxy)phenyl-hydrazone (FCCP) and oligomycin produced contraction similar to that promoted by phenylephrine. Phenylephrine-induced contraction was reduced by FCCP+oligomycin. In Ca2+-free, FCCP+oligomycin did not induce contraction. Response to FCCP+oligomycin was reduced upon Ca2+ repletion and this response was lower than that to phenylephrine. Ca2+ concentration was increased by FCCP+oligomycin. Since a profuse net of sarcoplasmic reticulum encloses mitochondria, a cross-talk between the two organelles may play an important role in the phenylephrine-induced contraction in presence of Ca2+ encountered in both sarcoplasmic reticulum and extracellular medium of anococcygeus cells.
Journal: Mitochondrion - Volume 6, Issue 2, April 2006, Pages 76–86