کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2081707 1545216 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Innate immunity and the role of the antimicrobial peptide cathelicidin in inflammatory skin disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Innate immunity and the role of the antimicrobial peptide cathelicidin in inflammatory skin disease
چکیده انگلیسی

Cathelicidin antimicrobial peptide is an important mediator of the innate immune response. In addition to its potent antimicrobial activity, cathelicidin has been shown to have chemoattractant and angiogenic properties. Recent research has demonstrated that, in addition to its aforementioned functions, cathelicidin plays an important role in the complex pathogenesis of several chronic inflammatory skin diseases. This review will present a concise overview of the role of cathelicidin in infection and in the development of atopic dermatitis, psoriasis and rosacea. This understanding will direct future research efforts to identify therapeutic approaches that use cathelicidin as a novel drug itself, or aim to modify its expression and regulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Disease Mechanisms - Volume 10, Issues 3–4, December 2013, Pages e79–e82
نویسندگان
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