Modeling of delayed type hypersensitivity (DTH) in the non-human primate (NHP)

Pre-clinical drug discovery persistently requires novel non-human primate (NHP) models for a quicker and more ethical compound profiling. Delayed type hypersensitivity (DTH) is a low invasive and non-terminal model based on the induction of local cellular immune responses. This review compiles the most common options or possible readouts for this model to become a relevant tool for pre-clinical compound testing in the immunology field.

Section editors:Margreet Jonker, Michel Vierboom and Bert 't Hart – Biomedical Primate Research Centre BPRC, Rijswijk, The Netherlands