Non-human primate models of multiple sclerosis

Because of their outbred nature and close genetic and immunological proximity to humans, non-human primates offer unique models for translational research into autoimmune-mediated inflammatory disorders. This review discusses non-human primate models of multiple sclerosis (MS), a progressive neurological disorder with a high unmet need for effective treatment. These models can help to bridge the gap between rodent experimental autoimmune encephalomyelitis (EAE) models and patients, which is a main cause of the present high attrition rate of new treatments.

Section editors:Margreet Jonker, Michel Vierboom and Bert 't Hart – Biomedical Primate Research Centre BPRC, Rijswijk, The Netherlands