Therapeutic modulation of microRNAs

The expression of microRNAs is commonly dysregulated in human disease. Targeting of microRNAs that are overexpressed and/or replacement of microRNAs whose expression is lost are two distinct approaches to treat diseases whose progression is advanced by microRNA dysregulation. In this review we will discuss recent findings with five specific microRNAs that highlight the opportunity associated with targeting microRNAs in human disease.