کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2082823 1080346 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antisense therapies for cardiovascular/metabolic diseases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Antisense therapies for cardiovascular/metabolic diseases
چکیده انگلیسی

RNA targeted therapeutics are being developed in a broad array of therapeutic areas, and more recently a growing number of RNA targeted antisense approaches for cardiovascular and metabolic diseases have progressed into clinical development. Cardiovascular and metabolic diseases are growing health issues with significant associated morbidity and mortality. RNA represents a growing and accessible target space that has been shown to be specifically and selectively targeted utilizing short single strand antisense oligonucleotides. Antisense drugs are relatively small synthetic oligonucleotides with predictable safety and pharmacokinetics across a given chemical platform. Once identified, the remaining risk in development as a therapeutic is associated with selection of the right target, sufficient to affect a clinically meaningful change in the course of disease. This review focuses primarily on the translated mRNAs currently being targeted using antisense therapies in cardiovascular and metabolic disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug Discovery Today: Therapeutic Strategies - Volume 10, Issue 3, Autumn 2013, Pages e165–e170
نویسندگان
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