Animal models for Alzheimer's disease – the industry perspective

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by intra- and extracellular deposits of aggregated proteins in the brains of affected individuals. Transgenic mice have been developed to show some of these characteristic histopathological hallmarks of AD in the brain. The availability of transgenic mice with different transgene combinations has given new insights into the pathology of AD and has suggested new approaches and routes to testing disease-modifying treatments.