Resting state EEG rhythms as network disease markers for drug discovery in Alzheimer's disease

Alzheimer's disease (AD) induces a widespread pathological extracellular accumulation of beta-amyloid (Aβ) peptides that affects cortical networks underpinning cognitive functions. This is related to abnormal functional and effective brain connectivity as revealed by graph markers of resting-state eyes-closed electroencephalographic (EEG) rhythms. Here we revised EEG studies in mild cognitive impairment and AD subjects showing that these markers are promising network disease endpoints for basic research and AD drug discovery.