Di-Mercapto Succinic Acid (DMSA) and vitamin C chelating potency in lead intoxication, regarding oxidative stress and apoptotic related proteins in rabbits

Free radicals interact with other molecules within cells. This can cause oxidative damage to proteins, membranes and genes. Oxidative damage has been implicated in the cause of many diseases such as cancer and Alzheimer’s and has an impact on the body’s aging process. External factors such as pollution, sunlight and smoking also trigger the production of free radicals and the process of programmed cell death (PCD) that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. The study was conducted to 42 male Orycytolagus Cuniculus rabbits. These animals were subdivided into seven groups approaching the comparison between treatment with vitamin C and Di-Mercapto Succinic Acid (DMSA) including positive and negative control groups. Lead ions concentration in blood, liver, kidney and brain were measured before and after treatments application. Apoptotic related proteins P53 and Bcl2 were estimated beside histological studies of tissues. Results revealed that it is more saving to use vitamin C as a lead chelator than DMSA. It is also can be stated that severe lead toxicity can be carcinogenic by increasing the oxidative stress in the biological systems as well as altering the balanced concentration of the apoptotic proteins.